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Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes.
Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, Råstam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, Altshuler D, Groop L, Florez JC. Sun MW, et al. Diabetes. 2006 Mar;55(3):849-55. doi: 10.2337/diabetes.55.03.06.db05-1418. Diabetes. 2006. PMID: 16505254
Of the seven genes that encode AMPK isoforms, we initially chose PRKAA2, PRKAB1, and PRKAB2 because of their higher prior probability of association with type 2 diabetes, based on previous reports of genetic linkage, functional molecular studies, expression patterns …
Of the seven genes that encode AMPK isoforms, we initially chose PRKAA2, PRKAB1, and PRKAB2 because of their higher prior prob …
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, Schlütermann D, Stuhldreier F, Wallot-Hieke N, José Mendiburo M, Cox J, Peter C, Bergmann AK, Stork B. Wu W, et al. Autophagy. 2021 Dec;17(12):3992-4009. doi: 10.1080/15548627.2021.1899667. Epub 2021 Mar 28. Autophagy. 2021. PMID: 33779513 Free PMC article.
In summary, we identified RIPK3 as an AMPK-activating kinase and thus a direct link between autophagy- and necroptosis-regulating kinases.Abbreviations: ACACA/ACC: acetyl-CoA carboxylase alpha; AMPK: AMP-activated protein kinase; ATG: autophagy-related; BECN1: beclin 1; GFP: gree …
In summary, we identified RIPK3 as an AMPK-activating kinase and thus a direct link between autophagy- and necroptosis-regulating kinases.Ab …
The pharmacogenetics of type 2 diabetes: a systematic review.
Maruthur NM, Gribble MO, Bennett WL, Bolen S, Wilson LM, Balakrishnan P, Sahu A, Bass E, Kao WH, Clark JM. Maruthur NM, et al. Diabetes Care. 2014;37(3):876-86. doi: 10.2337/dc13-1276. Diabetes Care. 2014. PMID: 24558078 Free PMC article. Review.
Significant medication-gene interactions for glycemic outcomes included 1) metformin and the SLC22A1, SLC22A2, SLC47A1, PRKAB2, PRKAA2, PRKAA1, and STK11 loci; 2) sulfonylureas and the CYP2C9 and TCF7L2 loci; 3) repaglinide and the KCNJ11, SLC30A8, NEUROD1/BETA2, UC …
Significant medication-gene interactions for glycemic outcomes included 1) metformin and the SLC22A1, SLC22A2, SLC47A1, PRKAB2, PR …
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours.
Ross FA, MacKintosh C, Hardie DG. Ross FA, et al. FEBS J. 2016 Aug;283(16):2987-3001. doi: 10.1111/febs.13698. Epub 2016 Mar 24. FEBS J. 2016. PMID: 26934201 Free PMC article. Review.
The multiple isoforms are of particular interest with respect to the roles of AMPK in cancer because the genes encoding some isoforms, such as PRKAA1 and PRKAB2 (encoding alpha1 and beta2), are quite frequently amplified in tumour cells, whereas the genes encoding others, …
The multiple isoforms are of particular interest with respect to the roles of AMPK in cancer because the genes encoding some isoforms, such …
Metformin ameliorates animal models of dermatitis.
Choi SY, Lee C, Heo MJ, Choi YM, An IS, Bae S, An S, Jung JH. Choi SY, et al. Inflammopharmacology. 2020 Oct;28(5):1293-1300. doi: 10.1007/s10787-020-00704-8. Epub 2020 Apr 28. Inflammopharmacology. 2020. PMID: 32347398
We found the expression levels of AMPK subunits including PRKAA1, PRKAA2, PRKAB1 and PRKAB2 are decreased in skin biopsies of dermatitis patients from multiple datasets. ...
We found the expression levels of AMPK subunits including PRKAA1, PRKAA2, PRKAB1 and PRKAB2 are decreased in skin biopsies of …
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Xue H, Cao H, Xing C, Feng J, Zhang L, Zhang C, Hu G, Yang F. Xue H, et al. Toxicology. 2021 Jul;459:152855. doi: 10.1016/j.tox.2021.152855. Epub 2021 Jul 10. Toxicology. 2021. PMID: 34252479
Furthermore, Cd caused the up-regulation of the mRNA levels of autophagy-related genes (ATG3, ATG5, ATG7, ATG12 and p62), AMPK (Prkaa1, Prkaa2, Prkab1, Prkab2, Prkag2, Prkag3) and Nrf2 (Nrf2, HO-1 and NQO1) signaling pathway, and the expression levels of LC3II/LC3I, …
Furthermore, Cd caused the up-regulation of the mRNA levels of autophagy-related genes (ATG3, ATG5, ATG7, ATG12 and p62), AMPK (Prkaa1, P …
[Partial isoform-specific expression and function of AMPK in ovarian carcinoma].
Yao S, Peng Q. Yao S, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020 Jul;36(7):628-633. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020. PMID: 32727648 Chinese.
Methods Real-time fluorescence quantitative PCR was used to detect the mRNA levels of AMPKalpha2 (PRKAA2), AMPKbeta1 (PRKAB1), PRKAB2, AMPKgamma1 (PRKAG1) and PRKAG2 in both ovarian cancer and benign ovarian tumor, meanwhile immunohistochemistry staining was used to …
Methods Real-time fluorescence quantitative PCR was used to detect the mRNA levels of AMPKalpha2 (PRKAA2), AMPKbeta1 (PRKAB1), PRK …
Study of candidate genes for glycolytic potential of porcine skeletal muscle: identification and analysis of mutations, linkage and physical mapping and association with meat quality traits in pigs.
Fontanesi L, Davoli R, Nanni Costa L, Scotti E, Russo V. Fontanesi L, et al. Cytogenet Genome Res. 2003;102(1-4):145-51. doi: 10.1159/000075740. Cytogenet Genome Res. 2003. PMID: 14970694
Several genes (PRKAA2, PRKAB1, PRKAB2, PRKAG3, GAA, GYS1, PYGM, ALDOA, GPI, LDHA, PGAM2 and PKM2), chosen according to their role in the regulation of the energy balance and in the glycogen metabolism and glycolysis of the skeletal muscle, were studied. ...Physical …
Several genes (PRKAA2, PRKAB1, PRKAB2, PRKAG3, GAA, GYS1, PYGM, ALDOA, GPI, LDHA, PGAM2 and PKM2), chosen according to their r …
Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China.
Yu H, Xu L, Liu H, Huang J, Luo L, Chen R, Xu J, Lin C, Chen W, Xie Y, Yang H, Kong D, Ding Y. Yu H, et al. Biomed Res Int. 2021 Sep 20;2021:5517364. doi: 10.1155/2021/5517364. eCollection 2021. Biomed Res Int. 2021. PMID: 34589546 Free PMC article.
This study found linkage disequilibrium existed between rs2167270 and rs4731426 of LEP, rs10889502 and rs17127107 of JAK1, rs2970847 and rs6821591 of PPARGC1A, rs249429 and rs3805486 of PRKAA1, rs1342382 and rs6588640 of PRKAA2, rs3766522 and rs6937 of PRKAB2, rs297 …
This study found linkage disequilibrium existed between rs2167270 and rs4731426 of LEP, rs10889502 and rs17127107 of JAK1, rs2970847 and rs6 …
27 results